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The GIPR variant (rs1800437, p.Glu354Gln) was associated with nausea only in people taking tirzepatide

If tiredness is still severe after eight weeks at a stable dose, it's worth speaking to your SheMed clinician persistent fatigue at that stage is less likely to be purely medication-related and may have another cause worth investigating

Adequate calcium intake (1,000-1,200mg daily), vitamin D supplementation (1,000-2,000 IU daily), and weight-bearing exercise during treatment help maintain bone integrity