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A brain-imaging study found that a TNF-alpha genetic variant associated with higher TNF levels was linked to anatomical brain changes in people with major depressive disorder.[ref] Elevated Interleukin-6 Encoded by the IL6 gene, interleukin-6 (IL-6) is another inflammatory cytokine shown to be consistently elevated in depression
About 1 in 8 US adults have used GLP-1s to manage diabetes, treat heart disease, or lose weight
Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats
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