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Knerr PJ, Mowery SA, Douros JD, Premdjee B, Hjollund KR, He Y, Kruse Hansen AM, Olsen AK, Perez-Tilve D, DiMarchi RD, et al

[1] Tirzepatide acts through two incretin receptors at once , GIP and GLP-1, adding a glucose-dependent insulin-secretion effect that an amylin analog does not have

Dec 29, 2025 Cagrilintide is a long-acting amylin receptor agonist that produces 10-12% body weight loss through mechanisms completely different from GLP-1s - dramatically slowing gastric emptying, suppressing appetite via brain amylin receptors, and reducing postprandial glucose

There was no significant difference in the rates of perioperative hypo or hyperglycemia, postoperative inotropic support, PONV, atrial fibrillation, and 30-day mortality