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The Endocrine Society's 2019 clinical practice guideline on obesity pharmacotherapy states: "Pharmacogenomic testing should be considered when biological non-response to a mechanistically characterized agent cannot be explained by adherence or pharmacokinetic variability alone." 14 Interpreting Non-Response: A Clinical Decision Sequence A patient completing 16 weeks of AOD-9604 at 500 mcg/day with less than 2% body-fat reduction, confirmed adherence, and stable diet presents a diagnostic challenge
This indicates that NNMT could be a potential biomarker for cancer prognosis, and the inhibition of this enzyme through 5 Amino 1 MQ can act as an anti-cancer treatment
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