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The overstimulation of neurons activates microglia, the resident immune cells of the brain, which release proinflammatory cytokines, such as TNF- and IL-1, as well as ROS (McConnell et al., 2015) (Figure 1)
It is not merely a matter of substituting one for the other but a nuanced exploration of the complexities involved
We need much bigger, better-designed studies before we can call this a proven treatment
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