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It is reported that one patient died of OMM after 63 months of misdiagnosed premalignant atypical melanocytic hyperplasia as a benign lentigo simplex ( BRAF V600E mutation, CDKN2A loss, PTEN loss and mTOR activation, CM precursor lesions followed by CM formation was observed in mice ( Recent sequencing studies have identified significant alterations in NRAS, BRAF, NF1, KIT, SF3B1, TP53 , and SPRED1 , informing potential targeted therapeutic strategies for MM ( NRAS , BRAF mutations are seen in MM, but more SF3B1 mutation and KIT alterations are found

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