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Notably, the ongoing phase I/II trial of XNW5004, an EZH2 inhibitor, in combination with pembrolizumab (NCT06022757) exemplifies the effort to reprogram epigenetic states and restore ICB sensitivity in solid tumors resistant to conventional treatments

This directly sensitizes osteoclasts to osteoclastogenic signals and entrains ROS-enhanced expression of cytokines that promote osteoclastic bone resorption

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The purity of -EC obtained was 96% on weight-based calculation with 4% impurity from phosphate used as buffer for reaction