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The American College of Physicians guidelines note that continued treatment is necessary to maintain weight loss, as discontinuation often leads to weight regain

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(9) S Bhalla, S Mehan, A Khan, and M U Rehman (2022) Protective role of IGF-1 and GLP-1 signaling activation in neurological dysfunctions Neuroscience and Biobehavioral Reviews, 2022 Nov, Volume 142, Page 104896