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This could be direct effects on the glycocalyx/endothelial function or potential anti-inflammatory effects. Heerspink noted most adults enrolled in the SURPASS trials had preserved kidney function, and additional studies enrolling adults with type 2 diabetes plus CKD with longer follow-up are needed
Long-term maintenance can mean staying on the medication, dropping to a lower dose, or transitioning off with a structured nutrition and exercise plan
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Certain mitochondrial proteins involved in the biosynthesis of iron-sulfur clusters (ISCs), such as cysteine desulfurase NFS1, ISC proteins, CISD1, and CISD2, have been shown to negatively regulate ferroptosis by reducing the availability of Fe 2+ [32,33,34,35]
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