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During molecular dynamic simulations with GLP-1 bound, the N-terminal helix was oriented vertically (black and blue arrows), whereas in the apo-form the ECD N-terminal helix was more dynamic and experienced both open and closed conformations (this is analogous to the suggested ECD dynamics for the glucagon receptor)
Furthermore, many individuals with gastroparesis are treated with acid-suppressive drugs, which significantly impair the GI tract's innate bactericidal activity
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