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To increase the plasma half-life by avoiding renal elimination, GLP-1 analogs were modified by adding acyl groups (liraglutide and semaglutide) or large molecules such as albumin (albiglutide) and the Fc portion of IgG (dulaglutide)
MOTS-c represents a frontier in metabolic peptide research rather than a proven alternative to tirzepatide
CV safety indicates noninferiority for major adverse cardiovascular events when superiority was not demonstrated
Gasiorek, A
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