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Signalling through IGFI and insulin receptors: where is the specificity
Sitagliptin administered to pregnant female rats and rabbits from gestation day 6 to 20 (organogenesis) was not teratogenic at oral doses up to 250 mg/kg (rats) and 125 mg/kg (rabbits), or approximately 30 and 20 times human exposure at the maximum recommended human dose (MRHD) of 100 mg/day based on AUC comparisons
For companies such as Sandoz, this nevertheless presents an opportunity to gain initial experience and secure market share
Understanding these effects helps differentiate expected medication responses from potentially serious complications like peptic ulcers
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