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Restoration of youthful IGF-1 profiles using a GH-axis intervention is not unambiguously supported as a longevity strategy the case rests primarily on body-composition and quality-of-life outcomes

Debated Unsettled Safety Issues Cancer Concerns about a possible connection between GLP-1 RAs and the development of neoplasms have spurred several investigations, especially on thyroid and pancreatic cancers due to a plausible mechanism and a large number of reports in the post-marketing phase [118, 128, 130]

For persistent nausea, temporary dose reduction or extending the time at a lower dose before escalation may be necessary

Collagen density increases, fine lines soften, skin thickness measurably increases