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It is plausible that GSTs serve two distinct roles in the development of drug resistance via direct detoxification as well as acting as an inhibitor of the MAP kinase pathway

Based on treatment purpose, the global iv glutathione treatment market is segmented into skin whitening & aesthetic treatments, antioxidant therapy, liver detoxification & support, anti-aging therapy, neurological & immune support, and others

This was further substantiated by the observation that inhibiting heightened GJ function with a GJ inhibitor in mice effectively diminished APAP toxicity, which correlated with reduced levels of oxidative stress in hepatocytes