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This behavior of the GS flux is caused by the competition between the higher inhibition of GS and GCL by GSH and the higher stimulation of GCL by estradiol [Figure 2]

doi: 10.1038/ncomms16040

Intranasal administration of PT-141 has been studied and shows approximately 25% bioavailability compared to subcutaneous injection, but is not the standard route in published protocols