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Semaglutide Works directly on appetite and hunger hormones Produces large, steady weight loss over many months Shows higher regain after stopping because its hormone-related effects end quickly Often continued as long as benefits outweigh risks Topiramate Works through appetite control, taste changes, and brain pathways Produces more moderate weight loss compared with semaglutide Weight regain may happen, but some people keep part of the weight off if lifestyle habits remain strong Long-term use is common but depends heavily on side-effect tolerance How Clinicians Decide the Length of Therapy Doctors usually recommend continuing treatment if: The medication is helping the patient lose weight or maintain weight loss Side effects are manageable The person has obesity-related health risks, such as diabetes, high blood pressure, fatty liver disease, or sleep apnea The patient feels the benefits outweigh the drawbacks Treatment may be reduced or stopped if: Serious side effects appear The medicine stops working A person becomes pregnant or plans to become pregnant Another health condition makes continuation unsafe Both medicines should be stopped gradually under medical supervision

Efficacy of Direct Injection of Etanercept Into Knee Joints for Pain in Moderate and Severe Knee Osteoarthritis