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Bile acid signaling in neurodegenerative and neurological disorders
Cell viability was not affected by any treatment (Figure S1 in File S1)
Reduced GSH levels following exhaustive exercise have been measured in red blood cells and muscle tissue, and the speed of glutathione repletion is a factor in recovery timeline and muscle function restoration
In addition, LipRSV treatment was associated with reduced BDNF and NGF levels, further indicating that redox modulation was not paralleled by neurotrophin restoration.Together, these results suggest limited therapeutic benefit of the formulation under the experimental conditions tested and highlight the complexity of linking redox modulation to functional behavioral outcomes in ASD models
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