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doi: 10.3390/microorganisms8071017 10 IlonenJLempainenJVeijolaR
This creates a risk of: Contamination with undisclosed active substances Inaccurate labelling , meaning the product may contain more or less of a compound than stated Adulteration with pharmaceutical agents, including stimulants or diuretics, which have been identified in some weight loss supplements by the MHRA Even where peptide compounds are genuine, oral bioavailability is a fundamental pharmacological challenge
Standardization of testing samples and methods is still lacking, and marked individual and metabolic variations exist (Kaltsas et al., 2024)
In Europe, Joint Clinical Assessments under the EU HTA Regulation centralize the evaluation of clinical value at the EU level, while pricing and reimbursement remain national decisions
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