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PE-22-28 (Mini-Spadin) blocks TREK-1 potassium channels with ~100-fold greater potency than its parent compound, demonstrating BDNF upregulation, rapid neurogenesis within 4 days, and cognitive benefits in stroke models (Djillani et al., 2017 in Frontiers in Pharmacology)
Mao L, Lv FF, Yang WF, Zhang TF, Li ZC, Li DQ, et al
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Thicker fillers do tend to be associated with bruising, in part because they need to be injected more deeply into the skin
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