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10.1038/nrdp.2017.40 25 HigginsJ.GreenS
Along with oxidative stress, these abnormal molecular changes lead to impaired mitochondrial respiratory function, ATP depletion, and various destructive cellular processes, such as mitochondrial fission, mitophagy, and programmed cell death, as we discuss below
This peptide is also able to cross the blood-brain-barrier, bypassing the vascular system and acting at the level of the central nervous system
These complexes showed photoinduced apoptotic cell death under visible light (IC 50 = 6.227.4 M, 400700 nm) and minimal cytotoxicity in the dark (IC 50 = 43.995.2 M), mainly in HeLa, HepG2, and A549 cancer cells
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