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This is crucial, given the strong link between MASH and cardiovascular, metabolic and renal conditions where semaglutide has already shown established health benefits. MASH is closely linked to metabolic risk factors like obesity, type 2 diabetes and high blood pressure

SCFAs can interact with free fatty acid receptor 3 present on brain endothelial cells (109), suppress inflammatory responses, and alleviate oxidative stress, thereby promoting BBB stability