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Mutations in methyl-CpG binding protein 2 (MeCP2), an epigenetic regulator, are the main cause of Rett syndrome

In order to generate this model and induce PCOS-like traits in adult offspring, pregnant dams were administered with a daily dose of the androgen dihydrotestosterone (DHT, 250 g/day) during gestational days 16, 17, and 18