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doi:10.1002/jor.21107
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In viral myocarditis caused by CVB3, macrophages are enriched in cardiac tissue as early as the third day post infection (239), and they secrete high levels of IL-1, which triggers the upregulation of NLRP3 in macrophages, potentially polarizing them to the M1 phenotype (240, 241)
88 The central strategy for overcoming resistance to immunotherapy is to achieve synergistic efficacy through combination regimens, which primarily follow two directions: first, combining immune checkpoint inhibitors with other immunotherapies to activate the immune system at multiple levels
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