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Some observational research has also suggested a slight increase in lung cancer risk linked to long-term, high-dose B6 and B12 supplementation, particularly among men and smokers, although this kind of study cannot prove that the supplements caused the cancers
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Often, the next test is serum methylmalonic acid (MMA), a functional marker of B12 deficiency that's produced when there's not enough active vitamin B12 present
EMBO J 44 , 65276555 (2025)
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