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The drug has also been related to the formation of silent gallstones and significant weight reduction in certain individuals [42]

However, the fouling of the fluid exchange membrane is a major concern for the delivery of insulin, and the pump can only release insulin with a low-concentration (1020 U/ml) and a short lifetime 22,33

Those results came from smaller studies, and the drug has not been validated through the large phase 3 program that turns a promising number into a dependable expectation

Pancreatitis: Though rare, semaglutide has been associated with an increased risk of pancreatitis, which is inflammation of the pancreas