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Participants were mostly women (65%), average age 55 years, with mean BMI 39typical of real-world obesity profiles
This superior efficacy helped it achieve global sales of ~US$16.4bn in 2024 (Mounjaro ~US$11.5bn and Zepbound ~US$4.9bn), rivalling semaglutide and completely overshadowing the sales of historical GLP-1s, such as exenatide, liraglutide and dulaglutide [FIGURE TWO]
Depending of substrates, there are different types of methyltransferases: S-methyltransferases, O-methyltransferases, and N-methyltransferases
Subcutaneous Injection (Recommended) Subcutaneous injection delivers MT-II directly into the fat layer beneath the skin, bypassing the digestive system entirely
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