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Future research should focus on addressing key technical bottlenecks in clinical translation, including optimizing targeting specificity, ensuring biosafety, and establishing standardized preparation processes, to accelerate the transition of these innovative technologies from the laboratory to clinical application, providing more comprehensive and reliable information support for clinical decision-making(Table 2)

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Sustained deficits in neuronal energy metabolism have been linked to the early stages of neurodegenerative processes, including the accumulation of beta-amyloid plaques and tau protein tangles, both hallmarks of Alzheimer's disease pathology [2]