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Funding This work was supported by the National Key Research and Development Program of China (2019YFE0108200), Sichuan International Science and Technology Cooperation Project (2022YFH0023), Science Popularization Base Project of Chengdu Science and Technology Bureau (2022-GH03-00003-HZ), West China Hospital 1.3.5 Project for Disciplines of Excellence (21HXFH002), West China Hospital Hospital-Enterprise Cooperation Clinical Research Innovation Project (2021HXCX04), and the National Natural Science Foundation of China (82001728)

Coenzyme A biosynthetic machinery in mammalian cells

The copper(II) ion in GHK-Cu is a cofactor for lysyl oxidase (LOX), the enzyme responsible for collagen and elastin cross-linking in blood vessel walls