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The sublingual formulation is designed for absorption through oral mucosa when placed under the tongue, typically taken first thing in the morning on an empty stomach following specific timing protocols to optimize absorption
This early investment not only advanced understanding of GLP-1 mechanisms in the brain, but also catalyzed subsequent funding from Novo Nordisk and GE HealthCare, paving the way for today's landmark phase 3 trials
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Importantly, body composition analyses using dual-energy X-ray absorptiometry (DEXA) and magnetic resonance imaging (MRI) have revealed that a significant proportion of this weight loss comes from fat mass rather than lean tissue
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