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Previous medications like Semaglutide (Wegovy/Ozempic) target only GLP-1, while Tirzepatide (Mounjaro/Zepbound) targets GLP-1 and GIP

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Tirzepatide's dual mechanism may confer additional metabolic benefits, though cardiovascular outcome trials are still ongoing to provide definitive evidence

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Using isotope tracing techniques, researchers observed increased FA uptake by GC B cells in vivo and demonstrated that GC B cells cultured in vitro preferentially metabolize FAs over glucose to generate significant amounts of acetyl-CoA

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