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6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB3 is a key glycolytic regulator upregulated by disturbed flow, promoting EC proliferation, inflammation, and angiogenesis, while laminar shear stress suppresses its expression to maintain EC quiescence [35, 38, 42, 44, 56, 202, 220]
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The introduction of oral GLP-1 formulations has removed the injection barrier but doesnt change underlying cost dynamics
(2016) 11:e0153380
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