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In contrast to prior studies 9,12,14,15 , which primarily relied on baseline or intention-to-treatstyle exposure definitions, AHM exposure in the present study was measured throughout the follow-up, and participants with high exposure ( 80% PDC) of the medication class were grouped under the class and compared, an approach not utilised in previous studies 9,12,13,15,31

Unlike older children or adults who might clearly describe how they feel, toddlers rely on their behavior and physical cues to communicate discomfort

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