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Crucially, the gut microbiome is essential for priming this response, as germ-free mice do not develop P.g -specific Th17 cells or severe periodontitis upon challenge, a response that is restored upon microbiota recolonization (Nagao et al., 2022)
It just needs the right signals
Some compounded formulations can tolerate controlled room temperature, up to 77 degrees F (25 degrees C), for a limited window that varies by formulation
Long-term safety and efficacy data are also essential
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