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Lancet 2:591593 McDowell G, Coutie W, Shaw C, Buchanan KD, Struthers AD, Nicholls DP (1997) The effect of the neutral endopeptidase inhibitor drug, candoxatril, on circulating levels of two of the most potent vasoactive peptides

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they observed that the mean enzymatic activities of xenobiotic metabolizing enzymes such as cytochrome P450 1A1 (CYP1A1), aromatase (CYP19A1), and glutathione-S-transferase (GST) were lower in three placental microsomes and subcellular membrane fractions