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Metabolomic analysis further demonstrated clearance of lipotoxic intermediates, decreased pro-inflammatory lipids, reduced collagen-derived metabolites, and elevated anti-inflammatory 15-HETE, confirming metabolic restoration at multiple regulatory levels
Additionally, there are many medications and potentially overlapping medical conditions that may affect eligibility
Of note, incidence of MTC was extremely low in all of the large cardiovascular outcome trials with no significant increase seen in GLP-1RA-treated individuals, although it should be highlighted that some of the trials did have a family history of MEN-2 as an exclusion criterion
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