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It is uniquely high in glycine, proline, and hydroxyproline, which are specific to the "unfolding" of connective tissue repair
Puts et al., 2017), which hampers the development of treatments
IGF-1 LR3 is more potent than regular IGF-1 because of the decreased binding of Long R3 IGF-1 to IGF binding proteins, allowing it to remain active up to 120 times longer compared to native IGF-1
The presence of Sec as a catalytic group is thought to ensure a rapid reaction with hydrogen peroxide and a fast reduction of GSH [65]
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