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268 AXL activation mediates both intrinsic and acquired resistance to targeted therapies (e.g., EGFR-TKIs in NSCLC, HER2 inhibitors in breast cancer), chemotherapy (e.g., cisplatin, gemcitabine), and antiangiogenic agents (e.g., bevacizumab)

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Typical trial exclusion criteria for retatrutide studies, consistent with those applied to similar investigational and licensed medicines in this class, have included: pregnancy or breastfeeding (with active contraception requirements during participation)

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