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Seek medical advice if you develop: Signs of severe dehydration : Persistent vomiting or diarrhoea, reduced urine output, dizziness, or confusion Symptoms of hypoglycaemia : Tremor, sweating, confusion, palpitations, or loss of consciousness, especially if taking insulin or sulphonylureas concurrently Allergic reactions : Rash, itching, swelling of the face or throat, or difficulty breathing Visual changes : Blurred vision or other eye problems, which may indicate diabetic retinopathy changes requiring ophthalmology review Symptoms of gallbladder disease : Right upper quadrant pain, jaundice (yellowing of skin or eyes), or fever Regarding bad breath specifically, consult your healthcare provider if halitosis: Persists despite good oral hygiene and hydration Is accompanied by other concerning symptoms such as unexplained weight loss (beyond expected therapeutic effect), fever, or persistent cough Significantly impacts your quality of life or social functioning Is associated with a sweet, fruity odour (which may indicate diabetic ketoacidosis, particularly in insulin-treated patients or those taking SGLT2 inhibitors concurrently) Regular monitoring is an integral part of tirzepatide therapy

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Ahmadi et al., 2020

While over-the-counter supplements are available, consulting a dermatologist ensures you get the right dosage and formulation.