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Phase 03
Activation of Killer Immunoglobulin-like Receptor (KIR)-DS1 on uNKs by HLA-C2 on trophoblasts stimulates the production of soluble Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and XCL1 from uNKs leading to increased migration of trophoblasts in vitro (52)
The subdued reaction of Th17 cells to IL-2, combined with alterations in PI3K/Akt/mTORC1 activation cues, explain the hampered differentiation of these cells in the absence of GLS (111)
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