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In vivo and in vitro models, it was found that in the IDH1 mutant glioma cells intervened by triptolide, the transcriptional activity of Nrf2 was suppressed, and the expression of genes related to glutathione anabolic metabolism (GCLC, GCLM, and SLC7A11) was significantly down-regulated
First small molecule permeable and selective for this target
Kanehisa, M., Furumichi, M., Sato, Y., Kawashima, M
Food sources In the US, mean dietary intakes of choline are well below the recommended adequate intake (AI) level
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