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Each component has distinct pharmacokinetic properties, with phentermine having a 20-hour half-life and topiramate extending to 21 hours, supporting twice-daily dosing regimens (Hendricks et al., Obesity, 2014)

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Because AOD9604 does not stimulate IGF-1 production and lacks strong GH receptor agonism, it may present a safer alternative for long-term OA treatment [1]