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DSIP had no sleep-inducing effect within the first hour post-injection, but other effects on sleep, such as a significant decrease in the percentage of stage I sleep, reduced awakenings, and increased total sleep time, were significant (t-test), although not significantly from the second to the sixth hour
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The use of Drosophila bring to the study of oxidative liver injury many advantages, including ease of genetic manipulation, availability of genetic mutants and constructs, ease of germ-free generation, relatively short lifespan, amenability to high-throughput screening, and overall cost relative to murine models 40
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