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Its selective permeability, governed by tight junctions, transport proteins, and metabolic enzymes, severely restricts brain penetration of macromolecular therapeutics, necessitating high systemic doses that cause hepatotoxicity and immunosuppression

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Rev Aquac 13:642663 Dawood, M.A.O., Ali, M.F., Amer, A.A., Gewaily, M.S., Mahmoud, M.M., Alkafafy, M., Assar, D.H., Soliman, A.A., Van Doan, H., 2021

Endogenous volatile organic compounds in breath and blood of healthy volunteers:Examining breath analysis as a surrogate for blood measurements