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Conditions like pernicious anaemia (an autoimmune condition affecting a protein called intrinsic factor vital for B12 absorption), stomach issues (such as from reduced stomach acid or certain medications like proton pump inhibitors), intestinal disorders (like Crohns disease or coeliac disease), or even surgical removal of parts of the small intestine (e.g., gastric bypass surgery) can prevent proper absorption
Much of the current evidence is preclinical (cell and animal studies), and human data is still limited
Some patients notice improved energy or mental clarity within 2448 hours, whilst others experience no immediate change, particularly if deficiency is severe
Early weight changes begin
