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Mahaffey KW, Neal B, Perkovic V, de Zeeuw D, Fulcher G, Erondu N, Shaw W, Fabbrini E, Sun T, Li Q, et al

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CJC-1295 without DAC (Mod GRF 1-29): 100 to 300 mcg subcutaneously 1 to 3 times daily

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By contrast, variants from higher-stringency campaigns (X(PC2)aX(PC2)e) evolved strong activity on procaspase-1, maintained activity on VAMP1 but lost activity on PC_SS1 (Extended Data Fig

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