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Hormone receptor-positive breast cancers, which rely on estrogen or progesterone for growth, are commonly treated with endocrine therapies such as Tamoxifen, a selective estrogen receptor modulator (SERM)
doi: 10.1016/j.yebeh.2019.106675 [PubMed] 31774955 Kapur J, Elm J, Chamberlain JM, Barsan W, Cloyd J, Lowenstein D, Shinnar S, Conwit R, Meinzer C, Cock H, Fountain N, Connor JT, Silbergleit R
A later review framed the molecule honestly as a still unresolved riddle, conceding that decades of study had not pinned down a mechanism or a confirmed physiological role (PMID 16539679)
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