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demonstrated that, MYC upregulates glutaminase (GLS) the enzyme that converts glutamine to glutamate, and MYC is frequently upregulated downstream of HIF signaling, suggesting an indirect route by which hypoxia can modulate glutamine metabolism (99)
More recent evidence demonstrates that although reduced ACC1 activity may decrease fatty acid synthesis, there is a paradoxical promotion of a pro-tumorigenic phenotype due to increased availability of acetyl-CoA for use by the enzyme histone acetyltransferase P300
These observations underscore the critical role of AOX-based strategies in advancing reproductive health and improving broader health outcomes, including those related to infertility
10.1038/s41467-020-15819-3 70
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