tirzepatide surmount 2 once weekly for the treatment of obesity in people with type diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial SURMOUNT-1: Tirzepatide Drastically Reduces Weight – tirzepatide trial results once weekly

And if you see an effect in areas of the brain, or you see the EEG, the bandwidth changing, you infer that youre getting blood-brain barrier penetration

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Mounjaro, DailyMed (2025) About body mass index (BMI), Centers for Disease Control and Prevention (2024) Zepbound, DailyMed (2025) Adult BMI categories, Centers for Disease Control and Prevention (2024) Body mass index is a barrier to obesity treatment, Frontiers in Endocrinology (2024) Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice

Almost certainly there is some confounding from diagnosis