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Dapagliflozin treatment ameliorates HG-induced oxidative stress and apoptosis, as manifested by decreased ROS levels, fewer apoptotic nuclei, and downregulated Nox4 and TGF- expression (124)

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The effective concentration in cellular assays falls in the 10 to 100 nM window, with an EC50 of approximately 10 nM

69,80 During aging, the level of 2-microglobulin (a component of major histocompatibility complex (MHC)-I) in plasma increases, leading to a proinflammatory phenotype in monocytes, cognitive decline, and regenerative impairments in the adult brain