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First, mechanistic work should integrate spatial metabolomics and mitochondrial proteomics to map ferroptosis pathways in cerebellar, spinal, and cardiac tissues from FRDA patients, with emphasis on the interaction between the ironsulfur cluster synthesis complex (NFS1ISCUISD11) and ferroptosis-related molecules (GPX4, Nrf2)

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Some healthcare providers will avoid prescribing these to people with an allergy to sulfonamide-containing antimicrobials

individuals with active renal disease or nephrolithiasis